Open AccessDescription of an albumin binding activity for Streptococcus suis serotype 2
Author(s) -
Quessy Sylvain,
Busque Philippe,
Higgins Robert,
Jacques Mario,
Dubreuil J.Daniel
Publication year - 1997
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1997.tb10249.x
Subject(s) - streptococcus suis , virulence , microbiology and biotechnology , serotype , albumin , biology , bovine serum albumin , streptococcaceae , biochemistry , gene , antibiotics
This study was undertaken to investigate the binding activity of Streptococcus suis serotype 2 to albumin. Using flow cytometry we observed a binding activity of S. suis to albumin for virulent as well as for avirulent isolates. Western immunoblots analysis revealed that a 39‐kDa S. suis protein was responsible, at least in part, for this binding activity. This protein showed high N‐terminal homology (95.6% for the first 23 residues) with a group A Streptococcus glyceraldehyde‐3‐phosphate dehydrogenase. Furthermore, the addition of albumin to the culture broth resulted in an increase in the virulence of S. suis strains in mice. These results suggest that an interaction with albumin could play a role in the pathogenesis of S. suis serotype 2 infections.