Open AccessTranscriptional downregulation of a mouse Golgi mannosidase gene following Salmonella typhimurium uptake into murine macrophages
Author(s) -
Schwan William R.,
Kopecko Dennis J.
Publication year - 1996
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1996.tb08580.x
Subject(s) - downregulation and upregulation , biology , salmonella , gene , microbiology and biotechnology , complementary dna , phagocytosis , population , gene expression , bacteria , biochemistry , genetics , demography , sociology
Uptake of Salmonella typhimurium into murine macrophage cells caused transcriptional downregulation of a mRNA population in eukaryotic cells after 2 h of infection. The cloned cDNA that was identified showed extensive homology with a murine α1,2‐mannosidase gene involved in N ‐oligosaccharide processing. These findings suggest a disruption of eukaryotic protein processing after phagocytosis of S. typhimurium by the murine macrophage cells.