Open AccessGenetics of Coxiella burnetii
Author(s) -
Thompson Herbert A.,
Suhan Michelle L.
Publication year - 1996
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1996.tb08569.x
Subject(s) - obligate , coxiella burnetii , biology , q fever , transformation (genetics) , genetics , pathogen , microbiology and biotechnology , heterologous , intracellular parasite , electroporation , gene , ecology
Those organisms considered to be obligate intracellular bacteria are interesting objects for genetic studies. Little is known about their mechanisms for natural genetic exchange. Many genes from the bacterium Coxiella burnetii , an obligate intraphagolysosomal pathogen, have therefore been cloned and characterized using the heterologous host Escherichia coli . Recently, use of electroporation methodology followed by long‐term selection periods have provided initial data on genetic transformation in C. burnetii .