Open AccessEvolutionary perspective on a composite Shigella flexneri 2a virulence plasmid‐borne locus comprising three distinct genetic elements
Author(s) -
Rajakumar Kumar,
Luo Fei,
Sasakawa Chihiro,
Adler Ben
Publication year - 1996
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1996.tb08502.x
Subject(s) - shigella flexneri , virulence , plasmid , biology , locus (genetics) , genetics , shigella , microbiology and biotechnology , mobile genetic elements , gene , escherichia coli
Abstract Nucleotide sequence analysis of a Shigella flexneri 2a virulence plasmid‐borne locus revealed that it comprised three distinct genetic elements: a stretch of colicin la/lb‐linked sequence, a truncated IS 911 element, and a third element containing two ORFs that shared a high level of similarity to a Salmonella‐specific chromosomal sequence. Examination of other known IS 911 ‐like sequences showed that these sequences also were frequently associated with other accessory elements and appeared to be prone to partial deletion events. Analysis of the data led to a model of the evolution of this unusual composite locus.