Open AccessMurine splenocyte proliferation by porin of Shigella dysenteriae type 1 and inhibition of bacterial invasion of HeLa cell by anti‐porin antibody
Author(s) -
Roy Sudipta,
Biswas Tapas
Publication year - 1996
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1996.tb08358.x
Subject(s) - shigella dysenteriae , porin , splenocyte , microbiology and biotechnology , shigellosis , hela , biology , shigella , antibody , shigella flexneri , salmonella , virology , cell , immunology , bacterial outer membrane , bacteria , biochemistry , escherichia coli , gene , genetics
The purified porin of Shigella dysenteriae type 1 showed strong mitogenic activity for murine splenocytes. Preincubation of S. dysenteriae type 1 with anti‐porin antibody reduced the bacterial plaque formation in HeLa cell monolayers by 45%. The two immunobiological activities indicate that porin might be important in the induction of protective immunity against shigellosis.