Open AccessTonB‐dependent iron supply in Salmonella by α‐ketoacids and α‐hydroxyacids
Author(s) -
Kingsley Robert,
Rabsch Wolfgang,
Roberts Mark,
Reissbrodt Rolf,
Williams Peter H
Publication year - 1996
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1996.tb08316.x
Subject(s) - siderophore , serratia marcescens , salmonella , microbiology and biotechnology , salmonella enteritidis , chemistry , serotype , bacteria , biology , enterobacteriaceae , biochemistry , escherichia coli , gene , genetics
A range of structurally diverse α‐ketoacids and α‐hydroxyacids promoted the growth of isolates of Salmonella serovars S. typhimurium, S. enteritidis, S. agona, S. paratyphi and S. Stanleyville in iron restricted conditions in the absence of functional siderophores. Growth stimulation, observed both in cross‐feeding tests on solid medium and in liquid cultures, and uptake of 55 Fe in the presence of α‐ketoisocaproic acid, were TonB dependent in S. typhimurium . In this respect the mechanism is distinct from a previously described Serratia marcescens system ( sfuABC ); the presence of the cloned sfuABC genes mediated tonB ‐independent uptake by S. typhimurium of iron complexed with α‐ketoacids.