Open AccessCyclic adenosine 3′,5′‐monophosphate and coryneform bacteria
Author(s) -
Dumay Valérie,
Vertes Alain,
Asai Yoko,
Inui Masayuki,
Kobayashi Miki,
Yukawa Hideaki
Publication year - 1995
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1995.tb07891.x
Subject(s) - brevibacterium , bacteria , adenylate kinase , extracellular , biochemistry , cyclase , adenosine , chemistry , chemically defined medium , amino acid , phosphate , carbon source , growth medium , biology , enzyme , microorganism , in vitro , genetics
We have detected cyclic AMP in the culture medium of amino acid‐producing coryneform bacteria. Extracellular concentrations of cyclic AMP vary depending on the nutritional medium, the growth phase and the carbon source. It is also shown that the activity of Brevibacterium flavum adenylate cyclase in intact cells is stimulated in the presence of glucose. Furthermore, addition of cyclic AMP to B. flavum cultures decreased amino acid production similarly to the effect produced by the addition of inorganic phosphate.