Open AccessVariability of Leishmania (Leishmania) infantum among stocks from immunocompromised, immunocompetent patients and dogs in Spain
Author(s) -
Jiménez Maribel,
FerrerDufol Montserrat,
Cañavate Carmen,
GutiérrezSolar Beatriz,
Molina Ricardo,
Lagun Fernando,
LópezVélez Rogelio,
Cercenado Emilia,
Daudén Esteban,
Blazquez Julio,
Guevara Conception Ladrón de,
Gómez Javier,
La Torre Julian,
Barros Carlos,
Altes Jordi,
Serra Teresa,
Alvar Jorge
Publication year - 1995
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1995.tb07777.x
Subject(s) - leishmania infantum , visceral leishmaniasis , leishmaniasis , leishmania , canine leishmaniasis , biology , coinfection , immunology , virology , medicine , parasite hosting , human immunodeficiency virus (hiv) , world wide web , computer science
Leishmania (Leishmania) infantum is the causative agent of both the cutaneous and visceral forms of leishmaniasis in southwest Europe; the dog is the main reservoir. In order to identify the L. (L.) infantum zymodemes present in Spain, a total number of 85 Leishmania stocks isolated from dogs (31), HIV‐positive patients (46) with visceral or cutaneous leishmaniasis, a patient with visceral leishmaniasis complicating renal transplantation (1) and immunocompetent patients (7) with visceral or cutaneous leishmaniasis, have been characterized by isoenzyme typing. All canine stocks were MON‐1, which is the most widespread zymodeme in the Mediterranean area. In immunocompetent patients three zymodemes were found: MON‐1 (2), MON‐24 (2) and MON‐34 (3). Nine different zymodemes were obtained in stocks from HTV co‐infected patients, indicating a higher variability of L. (L.) infantum amongst them: MON‐1 (in 21 stocks), MON‐24 (7), MON‐28 (1), MON‐29 (3), MON‐33 (7), MON‐34 (1) and MON‐183 (4). Two new zymodemes, MON‐198 (1) and MON‐199 (1), were described among HIV patients from Spain. The stock from the renal transplanted patient was MON‐1. The exclusive presence of certain zymodemes in immunocompromised patients and their absence in typical cases of cutaneous and visceral