Open AccessPlasmid rolling circle replication and its control
Author(s) -
Espinosa Manuel,
Del Solar Gloria,
Rojo Fernando,
Alonso Juan C.
Publication year - 1995
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1995.tb07707.x
Subject(s) - plasmid , rolling circle replication , replication (statistics) , biology , bacteria , genetics , dna , dna replication , guanine , replicate , origin of replication , gene , nucleotide , virology , mathematics , statistics
Abstract This review summarises current information on rolling circle replicating plasmids originally isolated from Gram‐positive bacteria with a low guanine and cytosine content in their DNA. It focuses on the peculiar biological features of these small, high copy number plasmids that replicate via an asymmetric RC mechanism. The regulation of plasmid copy number is also discussed.