Open AccessDr fimbriae coding region associated hemolytic activity of Escherichia coli
Author(s) -
Goluszko Pawel,
Nowicki Stella,
Kaul Anil K.,
Pham Tuan,
Nowicki Bogdan J.
Publication year - 1995
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1995.tb07692.x
Subject(s) - escherichia coli , hemolysis , fimbria , mutant , biology , microbiology and biotechnology , plasmid , enterobacteriaceae , pilus , gene , hemagglutinin (influenza) , coding region , genetics , immunology
We investigated the hemolytic activity of Escherichia coli strain EC901 carrying plasmid pBJN406 containing genes draA‐E involved in expression of the mannose‐resistant Dr hemagglutinin, and in its isogenic insertion mutants devised with Tn5, Tn3, and Tn phoA . While E. coli BN406 displayed rapid hemolytic activity against equine erythrocytes, insertion mutations in draD and draE , but not in draA, draB , and draC , abolished all hemolytic activity. These data suggest a role for draD and draE in the expression of hemolysis.