Open AccessA novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus
Author(s) -
Agata Norio,
Ohta Michio,
Mori Masashi,
Isobe Minoru
Publication year - 1995
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1995.tb07550.x
Subject(s) - bacillus cereus , microbiology and biotechnology , toxin , cereus , chemistry , bacillus (shape) , biology , bacteria , genetics
A vacuole‐formation substance, cereulide of Bacillus cereus , is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose‐dependent emesis in Suncus murinus , a new animal model of emesis. Vagotomy or a 5‐HT 3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5‐HT 3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp‐2 cells.