Open AccessActivation of the actinorhodin biosynthetic pathway in Streptomyces lividans
Author(s) -
Romero Natalia M.,
Mellado Rafael P.
Publication year - 1995
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1995.tb07453.x
Subject(s) - actinorhodin , biology , streptomyces fradiae , streptomycetaceae , gene , activator (genetics) , streptomyces coelicolor , streptomyces , genetics , actinomycetales , bacteria , mutant
Production of the antibiotic actinorhodin was activated in Streptomyces lividans under conditions in which it is not normally produced when transformed with an activator gene from S. lividans . The gene encodes a 86‐nucleotide transcript, responsible for the actinorhodin production phenotype, which is homologous to the 132 nucleotide transcript from S. fradiae , thought to act as a putative antisense RNA.