Open AccessNew butenolides from the photoconductivity screening of Streptomyces antibioticus (Waksman and Woodruff) Waksman and Henrici 1948
Author(s) -
Braun Dieter,
Pauli Niklaus,
Sequin Urs,
Zähner Hans
Publication year - 1995
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1995.tb07387.x
Subject(s) - streptomyces , serratia marcescens , chitinase , lactone , chemistry , stereochemistry , ring (chemistry) , bacteria , biology , organic chemistry , escherichia coli , biochemistry , enzyme , genetics , gene
Streptomyces antibioticus strain TÜ 99, from which a wide variety of active compounds had been isolated previously, was reinvestigated using an HPLC photoconductivity screening system. Four new compounds were isolated, characterized and their constitutions determined. All four were α,β‐unsaturated γ‐lactones; the most abundant compound 3 (C 10 H 16 O 4 ), as well as compound 1 (C 9 H 14 O 4 ) had a hydroxy group at C(5) of the lactone ring. The four lactones showed antibiotic activity against Pseudomonas aeruginosa and also a weak inhibition of the chitinase from Serratia marcescens .