Open AccessEnhanced expression of Plasmodium falciparum heat shock protein PFHSP70‐I at higher temperatures and parasite survival
Author(s) -
Biswas Sukla,
Sharma Yagya D.
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb07319.x
Subject(s) - parasite hosting , plasmodium falciparum , heat shock protein , shock (circulatory) , malaria , biology , plasmodium (life cycle) , hsp70 , immunology , gene , medicine , genetics , world wide web , computer science
The effect of various body temperatures, encountered during malaria fever, on the synthesis of Plasmodium falciparum heat‐shock protein called PFHSP70‐I and parasite growth rates among five different isolates are described. The results show that after the exposure of parasites at 39°C for 30 min the amount of PFHSP70‐I in all five isolates increased markedly and significantly, whereas parasite growth rates and the amount of total blood stage antigens remained almost unaffected. This indicates that the PFHSP70‐I gene responds to heat‐shock by producing higher amounts of PFHSP70‐I protein, presumably to protect the parasite from being killed during malaria fever.