Open AccessA haemolytic cell‐free preparation of Moraxella bovis confers protection against infectious bovine keratoconjunctivitis
Author(s) -
Billson F. Mark,
Hodgson Jennifer L.,
Egerton John R.,
Lepper Anthony W.D.,
Michalski Wojtek P.,
Leigh Schwartzkoff C.,
Lehrbach Philip R.,
Tennent Jan M.
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb07263.x
Subject(s) - microbiology and biotechnology , moraxella , biology , keratoconjunctivitis , virology , pilus , virulence , recombinant dna , bacteria , biochemistry , gene , genetics
Protection conferred by a cell‐free preparation from a haemolytic Moraxella bovis isolate, UQV 148NF, was compared to an equivalent fraction from a non‐haemolytic M. bovis isolate, Gordon 26L3, and to a recombinant DNA‐derived pili vaccine. Three groups of ten calves were vaccinated twice with one of the three preparations and, together with ten non‐vaccinated calves, challenged with virulent M. bovis isolate Dal 2d. Compared to the control group, significant protection was observed in the group receiving the pili vaccine and the group receiving the preparation from haemolytic isolate, UQV 148NF.