Open AccessAmino‐ and aminomethylcholesterol derivatives with fungicidal acitivity
Author(s) -
Elkihel L.,
Soustre I.,
Karst F.,
Letourneux Y.
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb07024.x
Subject(s) - ergosterol , sterol , biochemistry , auxotrophy , yeast , isomerase , reductase , biology , mutant , cytotoxicity , enzyme , chemistry , stereochemistry , in vitro , cholesterol , gene
Among a series of aminocholesterol derivatives synthesized, 7‐aminocholesterol is the strongest inhibitor of yeast cell growth. Using sterol auxotrophic mutant strains, we showed that this compound inhibits cell proliferation by interfering with ergosterol biosynthesis. The sterol pattern of treated cells revealed that 7‐aminocholesterol inhibits Δ 8 → Δ 7 ‐sterol isomerase and Δ 14 ‐sterol reductase as morpholine inhibitors. However, the novel feature of this compound is a strong cytotoxicity to yeast.