Open AccessInduction of respiration‐deficient mutants in Saccharomyces cerevisiae by chelerythrine
Author(s) -
Krivjanský Viktor,
Obernauerová Margita,
Ulrichová Jitka,
Šimánek Vilém,
Šubík Július
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb07012.x
Subject(s) - chelerythrine , sanguinarine , saccharomyces cerevisiae , phenanthridine , mutant , yeast , biochemistry , biology , respiration , chemistry , alkaloid , genetics , gene , botany , enzyme , protein kinase c
Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non‐fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae , chelerythrine, but not sanquinarine, induced cytoplasmic respiration‐deficient mutants. The petite clones that were analysed exhibited suppressiveness and contained different fragments of the wild‐type mitochondrial genome.