Open AccessProduction of aromatic α‐hydroxyacids by epimastigotes of Trypanosoma cruzi , and its possible role in NADH reoxidation
Author(s) -
Montemartini Marisa,
Santomé JoséA,
Cazzulo Juan José,
Nowicki Cristina
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb06808.x
Subject(s) - trypanosoma cruzi , aromatic amino acids , catabolism , tyrosine , biochemistry , phenylalanine , tyrosine aminotransferase , cytosol , amino acid , chemistry , biology , metabolism , enzyme , enzyme inducer , parasite hosting , world wide web , computer science
Epimastigotes of Trypanosoma cruzi in culture produce and excrete into the medium small amounts of phenyllactic acid and p ‐hydrocyphenyllactic acids, presumbly arising from the catabolism of the aromatic amino acids phenylalanine and tyrosine, respectively. This production might constitute a minor pathway for the reoxidation of cytosolic NADH, through the concerted action of tyrosine aminotransferase and aromatic α‐hydroxyacid dehydrogenase.