Open AccessLack of protection against gastric helicobacter infection following immunisation with jack bean urease: The rejection of a novel hypothesis
Author(s) -
Chen Minhu,
Lee Adrian,
Hazell Stuart L.,
Hu Pinjin,
Li Yiyang
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb06710.x
Subject(s) - urease , antibody , helicobacter , helicobacter pylori , immune system , immunology , biology , microbiology and biotechnology , immunity , adjuvant , humoral immunity , felis , cholera toxin , virology , medicine , enzyme , cats , biochemistry , genetics
The common mucosal immune system was stimulated by oral immunisation with jack bean urease and the adjuvant cholera toxin. A high level of local antibody and serum antibody was induced in mice following hyperimmunisation with this combination. No cross‐reacting antibody was found against either Helicobacter pylori or Helicobacter felis . No protection was observed against oral challenge of immunised mice with living H. felis thus disproving the interesting hypothesis of Pallen and Clayton that plant urease might induce a protective immunity against helicobacter infection.