Open AccessPorphyromonas gingivalis fimbriae and their synthetic peptides induce proinflammatory cytokines in human peripheral blood monocyte cultures
Author(s) -
Ogawa Tomohiko,
Uchida Hiroshi,
Hamada Shigeyuki
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb06707.x
Subject(s) - porphyromonas gingivalis , proinflammatory cytokine , monocyte , microbiology and biotechnology , peripheral blood , fimbria , immunology , chemistry , biology , inflammation , bacteria , escherichia coli , biochemistry , genetics , gene
Porphyromonas gingivalis fimbriae as well as synthetic peptides that mimic the fimbrial subunit protein, which includes the amino acid sequence XLTXXLTXXNXX, induced high production of proinflammatory cytokines such as interleukin‐1β, interleukin‐6, interleukin‐8, tumor necrosis factor‐α in human peripheral blood monocyte/macrophage cultures. Responses induced by some peptide segments were comparable to those induced by Escherichia coli lipopolysaccharides. A chemically modified peptide analogous to an active peptide segment was found to be antagonistic with regard to interleukin‐6 production induced by the native fimbriae. It may be suggested that P. gingivalis fimbriae and their degraded peptides function as proinflammatory agents in vivo, while certain analog peptides inhibited the process.