Open AccessBaeyer‐Villiger monooxygenases from microorganisms
Author(s) -
Wright Michael A.,
Taylor Ian N.,
Lenn Michael J.,
Kelly David R.,
Mahdi Jasem G.,
Knowles Christopher J.
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb06677.x
Subject(s) - pseudomonas putida , enantioselective synthesis , monooxygenase , bacteria , chemistry , enantiomer , stereochemistry , bicyclic molecule , camphor , pseudomonadaceae , pseudomonadales , microorganism , pseudomonas , organic chemistry , biology , enzyme , catalysis , cytochrome p450 , genetics
The oxidation of bicyclo[3.2.0]hept‐2‐en‐6‐one and 7‐ endo propylbicyclo[3.2.0]hept‐2‐en‐one was investigated using whole cells of Pseudomonas putida NCIMB 10007 and Xanthobacter autotrophicus NCIMB 10811. The bacteria demonstrated both regio‐ and enantioselective oxidation of the substrates. P. putida gave ‘mirror image’ with both substrates when the products of these oxidations were compared with cells grown on the different enantiomers of camphor. The regio‐ and enantioselectivity of the oxidation of the substrates by X. autotrophicus were enhanced by the 7‐ endo propyl substitution of bicyclo[3.2.0]hept‐2‐en‐6‐one.