Open AccessThe effect on enterotoxicity of protease purified from Vibrio cholerae O1
Author(s) -
Ichinose Yoshio,
Ehara Masahiko,
Honda Takeshi,
Miwatani Toshio
Publication year - 1994
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1994.tb06649.x
Subject(s) - vibrio cholerae , protease , microbiology and biotechnology , vibrionaceae , vibrio , serotype , biology , toxin , protease inhibitor (pharmacology) , bacteria , chemistry , biochemistry , virology , enzyme , virus , genetics , antiretroviral therapy , viral load
The effect on enterotoxicity of protease purified from Vibrio cholerae O1 was investigated by the inoculation of live vibrio cells into the protease‐treated loops of the ileal loop model. Fluid accumulation ratios in the protease‐treated loops were elevated in a dose‐dependent manner by challenge with live vibrio cells byt not that with toxin. An enhancement effect of protease on enterotoxicity was observed in both serotypes of V. cholerae O1 and V. cholerae non‐O1. It is suggested, therefore, that the enterotoxicity was enhanced by treatment with protease when live vibrio cells were inoculated into the ileal loops of rabbits.