Open AccessAnalysis of the Salmonella fim gene cluster: Identification of a new gene ( fimI ) encoding a fimbrin‐like protein and located downstream from the fimA gene
Author(s) -
Rossolini Gian Maria,
Muscas Patrizia,
Chiesurin Alessandra,
Satta Giuseppe
Publication year - 1993
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1993.tb06583.x
Subject(s) - biology , gene , gene cluster , fimbria , genetics , nucleic acid sequence , escherichia coli , pilus , coding region , open reading frame , peptide sequence , microbiology and biotechnology
The fimA gene coding for the major component (fimbrin) of type 1 fimbriae was mapped within the Salmonella typhi fim gene cluster, and its nucleotide sequence determined. The deduced amino acid sequence of S. typhi fimbrin is highly homologous to that of S. typhimurium type 1 fimbrin and showed similarity to that of other enterobacterial type 1 fimbrins. Downstream of fimA , an open reading frame was found, named fimI , able to encode a fimbrin‐like protein. The fimI product could represent the counterpart, in type 1 fimbriae, of the PapH protein involved in cell anchoring and length modulation of Escherichia coli Pap pili. This genetic organization was found to be common to other Salmonella serovars, including S. typhimurium and S. choleraesuis .