Open AccessStreptomyces lividans as host for heterologous protein production
Author(s) -
Anné Jozef,
Mellaert Lieve
Publication year - 1993
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1993.tb06561.x
Subject(s) - heterologous , streptomyces , biology , heterologous expression , secretion , bacteria , streptomycetaceae , secretory protein , microbiology and biotechnology , gene , host (biology) , actinomycetales , genetics , biochemistry , recombinant dna
Streptomycetes are Gram‐positive soil bacteria with a differentiated morphology. They are considered interesting candidates for the production of heterologous proteins for several reasons, including their efficient secretion mechanism by which the secreted proteins are localized into the culture supernatant. In view of this potential, this review article describes different aspects of gene expression and regulation in Streptomyces , and summarizes and discusses results obtained using Streptomyces lividans as host for secretion of heterologus proteins of prokaryotic and eukaryotic origin.