Open AccessInduction of aerial mycelium formation in a bld mutant of Streptomyces tendae by Borrelidin—a macrolide antibiotic
Author(s) -
Schüz Traugott Christoph,
Zähner Hans
Publication year - 1993
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1993.tb06548.x
Subject(s) - mycelium , streptomyces , mutant , metabolite , antibiotics , actinomycetales , streptomycetaceae , secondary metabolite , biology , stereochemistry , microbiology and biotechnology , chemistry , biochemistry , botany , bacteria , genetics , gene
In a screening programme for substances with morphogenic effects on the nikkomycin producer strain Streptomyces tendae Tü 901 we identified a metabolite, which induced aerial mycelium formation in the bld mutant Tü 901/S 2566‐EM 1. By using a HPLC UV/Vis absorbance spectral library we could confirm that this compound was identical with the macrolide antibiotic borrelidin. 100 ng borrelidin/paperdisc were sufficient to show an evident morphological effect.