Open AccessAnti‐ Candida activity of four antifungal benzothiazoles
Author(s) -
Bujdáková Helena,
Kuchta Tomáš,
Sidóová Eva,
Gvozdjaková Anna
Publication year - 1993
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1993.tb06471.x
Subject(s) - antifungal , microbiology and biotechnology , chemistry , biology
Anti‐ Candida activity of 6‐amino‐2‐ n ‐pentylthiobenzothiazole (I), benzylester of (6‐amino‐2‐benzothiazolylthio)acetic acid (II) and of 3‐butylthio‐(1,2,4‐triazolo)‐2,3‐benzothiazole (III) was followed and compared to that of 2‐mercaptobenzothiazole (IV). I and II exhibited good activity against the C. albicans yeast form, similar to IV. They were inhibitorily active against other Candida strains, IC 50 values being of the order of 10 −5 M, which means better activity than IV. Compound I also exhibited inhibitory activity on germ‐tube formation and mycelial growth in the C. albicans strains, while II, III and IV were not active in these tests. III was the least active form of the compounds tested, IC 50 values being of the order of 10 −4 M. All the compounds tested were highly active on a nystatin‐resistant C. albicans mutant, with IC 50 s of the order of 10 −6 M−10 −5 M.