Open AccessEffect of ethanol on the sterols of the fission yeast Schizosaccharomyces pombe
Author(s) -
Koukkou Anna I.,
Tsoukatos Demokritos,
Drainas Constantin
Publication year - 1993
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1993.tb06381.x
Subject(s) - lanosterol , schizosaccharomyces pombe , ergosterol , sterol , yeast , schizosaccharomyces , chemistry , ethanol , biochemistry , anaerobic exercise , biology , cholesterol , saccharomyces cerevisiae , physiology
Ergosterol, lanosterol and two further unidentified sterols were detected and quantified in Schizosaccharomyces pombe cell extracts. In cells grown under anaerobic conditions, the levels of these sterols were dramatically reduced with a concomitant increase of their squaline precursor as compared with cells growing under aerobic conditions. Presence of ethanol resulted in a decrease in the sterol content under aerobic conditions. On the contrary, under anaerobic conditions presence of ethanol resulted in a three‐fold increase of total sterols. Lanosterol was the main constituent of this elevation. It is suggested that lanosterol in parallel with unsaturated fatty acids is responsible for maintaining membrane integrity of S. pombe cells growing in the presence of ethanol.