Open AccessTransferrin synthesis by macrophages: up‐regulation by γ‐interferon and effect on lymphocyte proliferation
Author(s) -
Djeha A.,
PérezArellano J.L.,
Hayes S.L.,
Brock J.H.
Publication year - 1992
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1992.tb05912.x
Subject(s) - transferrin , interferon , lymphocyte activation , lymphocyte , macrophage , immunology , cell growth , transferrin receptor , biology , microbiology and biotechnology , chemistry , immune system , biochemistry , in vitro , t cell
We have investigated transferrin synthesis by human and mouse lymphoid and myeloid cells. It was found that transferrin synthesis is a property of mouse but not human macrophages, whereas in man T lymphocytes synthesised transferrin. Synthesis by mouse macrophages showed a dose‐dependent increase in response to γ‐interferon (γ‐IFN), but iron added as ferric nitrilotriacetate had no effect. Macrophage‐derived transferrin was found to contain iron already bound to it and was able to support Con A‐stimulated mouse lymphocyte proliferation.