Open AccessInactivation of the fis gene leads to reduced growth rate
Author(s) -
Nilsson Lars,
Verbeek Hans,
Hoffmann Ulf,
Haupt Michael,
Bosch Leendert
Publication year - 1992
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1992.tb05546.x
Subject(s) - chemostat , operon , bacteria , growth rate , biology , escherichia coli , wild type , microbiology and biotechnology , gene , mutant , genetics , geometry , mathematics
The FIS protein (factor for inversion stimulation) is known to activate the transcription of rRNA and tRNA operons in Escherichia coli . In this report the growth behaviour of a fis bacterium was studied under steady‐state conditions and in competition experiments with a wild‐type bacterium in a chemostat. The growth rate of the fis bacterium was reduced as compared to that of an isogenic wild‐type and this reduction increased linearly with increasing growth rate. A similar result was obtained in competition experiments in a chemostat, with the selection factor increasing linearly with the growth rate.