Open AccessAntitubercular activity of trifluoperazine, a calmodulin antagonist
Author(s) -
Ratnakar P.,
Murthy P. Suryanarayana
Publication year - 1992
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1992.tb05442.x
Subject(s) - trifluoperazine , calmodulin , antagonist , mycobacterium tuberculosis , isoniazid , microbiology and biotechnology , pharmacology , chemistry , tuberculosis , biology , biochemistry , medicine , receptor , enzyme , pathology
Trifluoperazine, a calmodulin antagonist, completely inhibited the growth of mycobacteria. The minimum inhibitory concentrations in shake cultures in a synthetic medium containing 0.2% Tween 80 were 5 and 8 μg/ml, respectively, for the human pathogenic strain Mycobacterium tuberculosis H 37 R v and M. tuberculosis resistant to isoniazid. When added to a growing culture of M. t tuberculosis H 37 R v on the 10th day (mid exponential phase), trifluoperazine 50 μg/ml further arrested growth of this organism. It is suggested that trifluoperazine or similar calmodulin antagonists might be useful as antitubercular drugs.