Open AccessCharacterisation of a novel repetitive DNA sequence from Mycobacterium bovis
Author(s) -
Doran T.J.,
Hodgson A.L.M.,
Davies J.K.,
Radford A.J.
Publication year - 1992
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1992.tb05413.x
Subject(s) - pentapeptide repeat , biology , tandem repeat , mycobacterium bovis , sequence (biology) , genetics , dna , computational biology , genomic dna , gene , open reading frame , peptide sequence , genome , mycobacterium tuberculosis , biochemistry , peptide , tuberculosis , medicine , pathology
We report characterisation of three copies of a novel repeat sequence isolated from a Mycobacterium bovis genomic library. The repeat occurs within open reading frames, potentially encoding a conserved tandem array of a pentapeptide sequence with the consensus X‐Gly‐Asn‐X‐Gly. The tandem array is present up to five times in M. bovis and it is proposed that they may occur in a family of genes expressing functionally related proteins. We postulate that these proteins may play a role in binding of M. bovis to host cell receptors.