Open AccessNitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis
Author(s) -
Novák Jan,
Hájek Petr,
< Rezanka Tomá< s,
Vanek Zdenko
Publication year - 1992
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1992.tb05040.x
Subject(s) - streptomyces avermitilis , avermectin , streptomyces , biosynthesis , biochemistry , fatty acid , metabolism , chemistry , nitrogen , strain (injury) , streptomycetaceae , bacteria , actinomycetales , biology , organic chemistry , gene , genetics , anatomy
Fatty acid composition was analysed in the producer of avermectins, Streptomyces avermitilis C‐18 grown in chemically defined medium with different nitrogen sources. Significant differences in nitrogen regulation of fatty acid biosynthesis were found in this strain in comparison with other streptomycetes studied so far. This finding could be explained at the level of regulation of branched‐chain amino acid metabolism.