Open AccessShigella ‐specific IgA in saliva of children with bacillary dysentery
Author(s) -
Schultsz C.,
Qadri F.,
Hossain S.A.,
Ahmed F.,
Ciznar I.
Publication year - 1992
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1992.tb04972.x
Subject(s) - shigella dysenteriae , shigellosis , shigella , shigella flexneri , bacillary dysentery , microbiology and biotechnology , serotype , dysentery , biology , shiga toxin , virology , immunology , salmonella , bacteria , virulence , escherichia coli , biochemistry , genetics , gene
To study the secretory immune response after Shigella infection, the anti‐lipopolysaccharide and anti‐Shiga‐toxin response in saliva, obtained from children with confirmed shigellosis and healthy children, were determined by enzyme‐linked immunosorbent assay and by Western blot. Children with infection showed high titers compared to healthy controls. After Shigella dysenteriae type 1 infection a significant change in titer could be observed in a large number of cases, in contrast to Shigella flexneri infection. It appeared that, in children living in endemic areas, infection with one serotype can give a rise in antibody titer to another serotype. This could be ascribed to polyclonal B cell activation since children in endemic areas routinely show relatively high titers to Shigella antigens. We conclude that the dynamics of salivary anti‐ Shigella LPS and anti‐Shiga‐toxin in children with dysentery indicate that it can be applied to studies of immune response in shigelosis for epidemiological and vaccination purposes.