Open AccessHistone preopsonisation increases the respiratory burst response of phagocytes to Pneumocystis carinii
Author(s) -
Taylor Mark B.,
Brown Ivor N.
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb05129.x
Subject(s) - pneumocystis carinii , respiratory burst , phagocyte , macrophage , phagocytosis , microbiology and biotechnology , respiratory system , immunology , biology , histone , chemiluminescence , chemistry , biochemistry , human immunodeficiency virus (hiv) , in vitro , organic chemistry , anatomy , gene , pneumocystis jirovecii
Preincubation of Pneumocystis carinii with histone caused an increase in polymorphonuclear leucocyte and macrophage chemiluminescence when parasites were mixed with phagocytes compared with that obtained when unopsonised parasites were used. Toxic oxygen moieties released during the respiratory burst may cause tissue damage.