Open AccessInfluence of yeasts and of their constituents on nucleoside uptake in peritoneal murine macrophages
Author(s) -
Busolo Franco,
Palù Giorgio,
Conventi Luciano
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb05116.x
Subject(s) - laminarin , zymosan , yeast , polysaccharide , nucleoside , biochemistry , monosaccharide , candida albicans , uridine , saccharomyces cerevisiae , cell wall , microbiology and biotechnology , biology , chemistry , in vitro , rna , gene
A marked reduction of [ 3 H]‐uridine uptake was observed when mouse peritoneal macrophages (pMφ) were exposed to heat‐killed Candida albicans or Saccharomyces cerevisiae . By contrast, an increased nucleoside uptake was promoted by yeast products such as zymosan, laminarin, or yeast cell‐wall extracts, which are mainly composed of β‐glucans and α‐mannans. In a search for the active fungal component(s), the uptake process was shown ti be differently affected by monosaccharides and polysaccharides. These findings support the view that a specific recognition of a pMφ membrane receptor is mediating the effect of the various substances.