Open AccessA new cyclitol derivative influences inositol metabolism in Neurospora crassa
Author(s) -
Szabó G.,
Schablik M.,
Kiss Á,
Koncz Cs.,
Bognár R.,
Pelyvás I.,
Sztaricskai F.
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04832.x
Subject(s) - neurospora crassa , cyclitol , crassa , inositol , biochemistry , neurospora , biology , atp synthase , metabolism , intracellular , enzyme , gene , receptor , mutant
Cyclitol derivatives have been synthesized and screened for growth inhibitory effect upon prokaryotic and eukaryotic organisms. One derivative, (2S, 3R, 5R)‐3‐azido‐2‐benzoyloxy‐5‐hydroxycyclohexanone, was studied in detail: it has no effect upon bacteria, but it is inhibitory to Neurospora crassa . In Neurospora crassa it increased the amount of myo ‐inositol‐1‐phosphate synthase and inhibited the activity of myo ‐inositol‐monophosphatase. The enhanced synthesis of myo ‐inositol‐1‐phosphate synthase was the consequence of lowering the intracellular inositol concentration. Li + treatment of Neurospora crassa has effects similar to those of P.I.‐658.