Open AccessRates of germ tube formation from growing and non‐growing yeast cells of Candida albicans
Author(s) -
Buchan Arlene D.B.,
Gow Neil A.R.
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04704.x
Subject(s) - yeast , germ tube , candida albicans , biology , sexual dimorphism , corpus albicans , rna , cell growth , biochemistry , microbiology and biotechnology , gene , endocrinology
The rates of germ tube formation from growing and non‐growing yeast cells of Candida albicans were investigated using a protocol for dimorphism regulated by temperature and pH. Stationary‐phase cells formed germ tubes less rapidly than yeast cells that were preincubated in fresh growth medium prior to induction of dimorphism by an upshift in temperature or pH. On the basis of experiments using inhibitors of macromolecular biosyntheses it is suggested that the accelerated growth kinetics required de novo RNA and protein biosynthesis, but not DNA synthesis. The results suggest that metabolically active yeast cells are better able to undergo dimorphism than non‐growing cells.