Open AccessEnhanced clearing of Helicobacter pylori after omeprazole plus roxithromycin treatment
Author(s) -
Cellini Luigina,
Marzio Leonardo,
Di Girolamo Arturo,
Allocati Nerino,
Grossi Laurino,
Dainelli Benedetto
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04606.x
Subject(s) - omeprazole , roxithromycin , helicobacter pylori , gastritis , medicine , gastroenterology , minimum inhibitory concentration , spirillaceae , antibacterial agent , pharmacology , microbiology and biotechnology , antibiotics , biology , erythromycin
The in vitro antibacterial activity of omeprazole against eight strains of Helicobacter pylori was evaluated. Minimum inhibitory concentration (MIC) values were 32 μg/ml and 64 μg/ml (MIC 50 and MIC 90 respectively). We performed a randomized single blind study comparing the efficacy of omeprazole alone (for 4 weeks) or combined with roxithromycin (for 2 weeks) in the treatment of duodenal ulcer and chronic active gastritis associated with H. pylori infection, H. pylori was eradicated in 75% of patients treated with omeprazole alone whereas the patients treated with the combination of these drugs were completely free from H. pylori at the end of the therapy.