Open AccessThe novel gene trs1 encodes an essential protein for the transition from mitotic cell cycle to resting state in Schizosaccharomyces pombe
Author(s) -
Kitamura Kenji,
Shimoda Chikashi
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04559.x
Subject(s) - schizosaccharomyces pombe , mutant , heat shock , schizosaccharomyces , microbiology and biotechnology , biology , heat shock protein , mitosis , yeast , shock (circulatory) , gene product , gene , cell cycle , genetics , gene expression , medicine
A novel gene trs1 in the fission yeast Schizosaccharomyces pombe has been genetically defined. The trs1 mutant showed several intriguing phenotypes. Cells were sensitive to starvation and rapidly lost viability in the stationary phase; cells in the stationary phase were sensitive to heat shock. Some heat‐shock proteins were not induced and the heat‐shock response in log‐phase cells was defective. These mutant phenotypes strongly suggest a vital function of the trs1 gene product for transition from the G1 to G0 phase on starvation and for the normal heat‐shock response.