Open AccessEffect of azasqualene on hopanoid biosynthesis and ethanol tolerance of Zymomonas mobilis
Author(s) -
Horbach Silke,
Neuss Burkard,
Sahm Hermann
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04553.x
Subject(s) - zymomonas mobilis , ethanol , biochemistry , biosynthesis , microbiology and biotechnology , squalene , chemistry , biology , hopanoids , enzyme , ethanol fuel , paleontology , structural basin , source rock
Summary The effect of 2‐aza‐2,3‐dihydrosqualene (azasqualene) on growth and hopanoid content of Zymomonas mobilis was investigated. Concentrations of 4–7 μM azasqualene resulted in a diminishment of growth and hopanoid content of cells with a simultaneous accumulation of squalene. The inhibitory effect of azasqualene was enhanced by ethanol. Furthermore, the importance of hopanoids for the ethanol tolerance of Z. mobilis was demonstrated by an increased growth inhibition of cells with reduced hopanoid content by ethanol.