Open AccessSuperoxide dismutases of pathogenic and non‐pathogenic Streptococcus suis type 2 isolates
Author(s) -
Langford P.,
Williams A.E.,
Kroll J.S.
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04374.x
Subject(s) - virulence , superoxide dismutase , microbiology and biotechnology , streptococcus suis , intracellular , biology , pathogenic bacteria , pathogenicity , streptococcus , enzyme , bacteria , gene , genetics , biochemistry
Summary Pathogenic and non‐pathogenic isolates of Streptococcus suis type 2 were screened to determine whether differences in superoxide dismutase (SOD) synthesis could explain the observed differences in their pathogenicity and intracellular fate in macrophages. A single band of SOD activity of similar R f value was visualised in PAGE gels in all isolates and inhibition studies suggested that the cofactor present was manganese. There was no correlation between specific SOD activity and virulence. It is unlikely, therefore, that SOD produced by S. suis type 2 mediates intracellular survival of pathogenic isolates in macrophages.