Open AccesspH regulation of penicillin production in Aspergillus nidulans
Author(s) -
Shah Ajit J.,
Tilburn Joan,
Adlard Maxwell W.,
Arst Herbert N.
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04349.x
Subject(s) - aspergillus nidulans , penicillin , microbiology and biotechnology , aspergillus , chemistry , biology , antibiotics , biochemistry , mutant , gene
Summary As shown by both bioassay and high‐performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pac C which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in the pal A, pal B, pal C, pal E or pal F genes which mimic the effects at growth at acid pH.