Open AccessAntibodies to listeriolysin O reflect the acquired resistance to Listeria monocytogenes in experimentally infected goats
Author(s) -
Miettinen Ari,
Husu Jaana
Publication year - 1991
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1991.tb04344.x
Subject(s) - listeria monocytogenes , listeriolysin o , antibody , microbiology and biotechnology , biology , serotype , listeria , virology , bacteria , immunology , genetics
Summary We induced experimental listeriosis in goats by two sequential oral inoculations of Listeria monocytogenes serovar 1/2a at 8 months' interval. Immunoblot analysis with the goat sera demonstrated listeriolysin O (LLO) as the principal protein antigen of L. monocytogenes . Pre‐existing antibodies to LLO were, depending on their initial level, associated with either mild clinical symptoms of short duration or the total absence of clinical symptoms. Similarly, the presence and development of such antibodies correspond with the disappearance pattern of L. monocytogenes from the gastrointestinal tract. These findings suggest that an association exists between antibodies to LLO and acquired resistance to Listeria infections.