Open AccessAntibiotic sensitivity of the ribosomes of the ultra‐thermophilic archaebacterium Pyrococcus woesei
Author(s) -
Catani M. Valeria,
Altamura Sergio,
Londei Paola
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb13990.x
Subject(s) - thermophile , thermotoga maritima , ribosome , biology , hyperthermophile , pyrococcus furiosus , halophile , microbiology and biotechnology , antibiotics , escherichia coli , bacteria , biochemistry , genetics , archaea , rna , gene
1. Summary The effect of several antibiotics on polypeptide synthesis and translational accuracy by ribosomes from the ultra‐thermophilic archaebacterium Pyrococcus woesei was investigated. Pyrococcus was found to be unique among the sulfur‐dependent extreme thermophiles in being sensitive to the miscoding‐inducing action of aminoglycoside antibiotics (except streptomycin). On the whole, the antibiotic sensitivity patterns indicate phylogenetic closeness of Pyrococcus to the methanogenic‐halophilic branch of the archaebacterial tree.