Open AccessIsolation and characterization of staphyloferrin A, a compound with siderophore activity from Staphylococcus hyicus DSM 20459
Author(s) -
Meiwes J.,
Fiedler H.P.,
Haag H.,
Zähner H.,
KonetschnyRapp S.,
Jung G.
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb13863.x
Subject(s) - isolation (microbiology) , siderophore , microbiology and biotechnology , staphylococcus , biology , chemistry , staphylococcus aureus , bacteria , genetics
A highly hydrophilic compound was isolated from low iron culture broth of Staphylococcus hyicus DSM 20459 which exhibits siderophore activity to the producer and 37 other staphylococci. The previously unknown metabolite was designated staphyloferrin A and constists of two molecules of citric acid, each linked to d ‐ornitine by an amide bond. Using an iron‐pair HPLC‐system we detected staphyloferrin A and a second iron regulated compound (staphyloferrin B) in the culture fluid of several Staphylococcus strains. We found no evidence that staphylococci synthesize catecholor hydroxamate‐type siderophores.