Open AccessBioconversion of 19‐deformyl‐5‐ O ‐desosaminyl tylonolide to 19‐deformyl‐4′‐deoxydesmycosin (TMC‐016)
Author(s) -
Fujiwara Tatsuro,
Takenaka Satoshi
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb04183.x
Subject(s) - bioconversion , micromonospora , chemistry , stereochemistry , organic chemistry , biology , fermentation , streptomyces , bacteria , genetics
Bioconversion of 19‐deformyl‐5‐ O ‐desosaminyl tylonolide (1) to 19‐deformyl‐4′‐deoxydesmycosin (3) was performed by using a mycinamicin‐producing Micromonospora species. Compound 1 at low concentrations was completely converted to compound 3, however, the conversion to compound 3 was suppressed at high concentrations and 19‐deformyl‐4′‐deoxy‐2″, 3′‐di‐ O ‐demethyl‐desmycosin (2), an intermediate leading to compound 3 accumulated.