Open AccessAutolysins are direct involved in the bactericidal effect caused by penicillin in wild type and in tolerant pneumococci
Author(s) -
López Rubens,
Ronda Concepción,
García Ernesto
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb04019.x
Subject(s) - lytic cycle , microbiology and biotechnology , streptococcus pneumoniae , penicillin , amidase , penicillin amidase , enzyme , mutant , arginase , biology , chemistry , antibiotics , biochemistry , virology , arginine , amino acid , gene , virus
The two pneumococcal autolytic enzymes (an N‐acetylmuramoyl‐ l ‐alanine amidase and an endo ‐ β ‐1,4‐ N ‐acetylglucosaminidase) are directly involved in the penicillin‐induced killing of Streptococcus pneumoniae . The activity of these lytic enzymes was efficiently controlled in tolerant mutants under physiological conditions.