Open AccessSuppression of tyrocidine production by purine nucleotides and related substances in Bacillus brevis
Author(s) -
Oyama Masakazu,
Kubota Kou
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb04010.x
Subject(s) - nucleotide , adenosine , purine , bacillus (shape) , biochemistry , biology , chemistry , microbiology and biotechnology , enzyme , gene
Bacillus brevis (ATCC 8185) produces an antibiotic peptide, tyrocidine. We found that adenosine or 5′‐AMP suppressed the production of tyrocidine with half‐maximum inhibition at 100‐ 300 μM. This inhibition was specific to the production of tyrocidine since neither adenosine nor 5′‐AMP showed any effect on bacterial growth. Cyclic nucleotides had no effect. These results suggest that adenosine, 5′‐AMP or its metabolite was specifically involved in the regulation of tyrocidine production.