Open AccessCorrelation between the effects of fosfomycin and chloramphenicol on Escherichia coli
Author(s) -
MenginLecreulx Dominique,
Heijenoort Jean
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb03984.x
Subject(s) - fosfomycin , chloramphenicol , lysis , peptidoglycan , pentapeptide repeat , microbiology and biotechnology , chemistry , antibiotics , escherichia coli , biology , biochemistry , enzyme , peptide , gene
It was speculated that the increase of the UDP‐GlcNAc pool observed with chloramphenicol can modulate the residual PEP: UDP‐GlcNAC‐enolpyruvate activity of fosfomycin‐treated cells. This provided an explanation on how chloramphenicol can insure the formation of enough UDP‐Mur‐NAc‐pentapeptide to sustain peptidoglycan synthesis at a rate that will antogonize fosfomycin‐induced lysis.