Open AccessCross resistance between oxytetracycline and oxolinic acid in Aeromonas salmonicida associated with alterations in outer membrane proteins
Author(s) -
Barnes A.C.,
Lewin C.S.,
Hastings T.S.,
Amyes S.G.B.
Publication year - 1990
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1990.tb03912.x
Subject(s) - oxolinic acid , aeromonas salmonicida , oxytetracycline , bacterial outer membrane , microbiology and biotechnology , mutant , biology , strain (injury) , antibiotics , bacteria , chemistry , biochemistry , tetracycline , escherichia coli , genetics , gene , nalidixic acid , anatomy
Oxytetracycline resistant mutants of Aeromonas salmonicida isolated from mutation frequency experiments showed decreased susceptibility to oxolinic acid. Outer membrane preparations of these resistant mutant strains revealed a major protein, with a molecular mass of approximately 37 kDa, which was not present in significant quantities in the parent strain.